CD45R (human, mouse)

Article No AFC-4673-2
Product Type Antibodies Primary
Application FC, IP, IHC-P, IHC-Fr, ICC, FA
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone RA3-6B2
Clone Type monoclonal
Concentration 1 mg/ml
Description Rat Monoclonal to CD45R (human, mouse)
Supplier BioSite Flow
Immunogen Abelson murine leukemia virus-induced pre-B tumor cells
Isotype IgG2a
Keywords Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Veterinary), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Rodent), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), CD Antigens & MHC (Veterinary), CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human)
Notes CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Purification Purified by protein-G affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human, mouse, cat/feline
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Technical Specifications The rat monoclonal antibody RA3-6B2 recognizes an epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells. T cells detected by this antibody are supposed to be in activated state.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

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Species reactivity:

human, mouse, cat/feline human mouse

Suggested protocols:

Immunoprecipitation

Immunoprecipitation