Article No
AFC-7LRD47-0.1
Application | FC, IP, IHC, ICC |
Article No | AFC-7LRD47-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | RA3-6B2 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Ms CD45R Purified Low Endotoxin |
Supplier | Nordic Biosite |
Format | Purified Low Endotoxin |
Immunogen | Abelson murine leukemia virus-induced pre-B tumor cells |
Isotype | IgG2a k |
Keywords | Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Veterinary), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Rodent), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), CD Antigens & MHC (Veterinary), CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human) |
Notes | CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells. |
Alias Names | PTPRCR, T200R |
Previous Article No | AFC-4673-2, AFC-7LRD47-0.1 |
Product Type | Antibodies Primary |
Protocol | Functional application: Modulation of B cell responses. Flow cytometry: Recommended dilution: 1-4 µg/ml |
Purification | Purified by protein-G affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | cat/feline, mouse, human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4 |
Technical Specifications | The rat monoclonal antibody RA3-6B2 recognizes an extracellular epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells. T cells detected by this antibody are supposed to be in activated state. |
Product Page Updated | 2024-01-03T12:18:20.318Z |