Article No
AFC-JUIIHJ-0.1
Application | FC, IP, WB, IHC, ICC |
Article No | AFC-JUIIHJ-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | CD28.2 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD28 Purified Low Endotoxin |
Supplier | Nordic Biosite |
Entrez Gene ID | 940 |
Format | Purified Low Endotoxin |
Immunogen | DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA |
Isotype | IgG1 k |
Keywords | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
Notes | CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader. |
Alias Names | TP44 |
Previous Article No | AFC-4641-2, AFC-JUIIHJ-0.1 |
Product Type | Antibodies Primary |
Protocol | Functional application: T cell costimulation. Flow cytometry: Recommended dilution: 1-12 µg/ml |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research area | Immunology |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | monkey, human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4 |
Technical Specifications | The mouse monoclonal antibody CD28.2 recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. |
UniProt Number | P10747 |
Product Page Updated | 2024-01-03T12:18:20.318Z |