CD42b

Article No AFC-4616-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, ICC, ELISA
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone AK2
Clone Type monoclonal
Concentration 1 mg/ml
Description Mouse Monoclonal to CD42b
Supplier BioSite Flow
Immunogen Human platelets
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Technical Specifications The mouse monoclonal antibody AK2 recognizes CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d._x000D_ <br>_x000D_ <b>HLDA V: WS Code P024</b>
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human human