CD235a

Article No AFC-4605-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IHC-P, IHC-Fr
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone JC159
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to CD235a / Glycophorin A
Supplier BioSite Flow
Immunogen Membrane preparation from splenic hairy cell leukemia
Isotype IgG1
Keywords CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human)
Notes CD235a (Glycophorin A, GPA) is a transmembrane sialoglycoprotein expressed on erythrocytes and their precursors. Similarly to glycophorin B (GPB), these molecules provide the cells with a large mucin-like surface, which minimalizes aggregation between erythrocytes in the circulation. GPA is the carrier of blood group M and N specificities, while GPB accounts for S, s and U specificities. CD235a is a receptor of Hsa, an Streptococcus adhesin.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human, rat
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The mouse monoclonal antibody JC159 recognizes an epitope between amino acids 27 and 40 of the extracellular portion of CD235a (glycophorin A), a sialoglycoprotein expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL. The antibody does not react with glycophorin B.
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, rat human rat