Article No
AFC-ZZTFWU-0.1
Application | FC, IP, WB, IHC |
Article No | AFC-ZZTFWU-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | S5/1 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD88 Purified |
Supplier | Nordic Biosite |
Entrez Gene ID | 728 |
Format | Purified |
Immunogen | Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR |
Isotype | IgG2a k |
Keywords | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
Notes | CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis. |
Alias Names | C5A, C5R1, C5AR1 |
Previous Article No | AFC-4575-2, AFC-ZZTFWU-0.1 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: Recommended dilution: 3-12 μg/ml. |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research Area | Immunology |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | rabbit, mammals, cow/bovine, human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The mouse monoclonal antibody S5/1 recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade. |
UniProt Number | P21730 |
Product Page Updated | 2024-01-03T12:18:20.318Z |