CD105 (mouse)

Article No AFC-4561-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, IHC-Fr
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone MJ7/18
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Rat Monoclonal to CD105 (mouse)
Supplier BioSite Flow
Immunogen Inflamed mouse skin
Isotype IgG2a
Keywords CD and Related Antigens & MHC (Rodent)
Notes CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Purification Purified by protein-G affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity mouse
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The rat monoclonal antibody MJ7/18 reacts with CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

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Species reactivity:

mouse mouse