Article No
AFC-7EV6N1-0.1
Application | FC, IP, WB, IHC, ICC |
Article No | AFC-7EV6N1-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | NGFR5 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD271 Purified |
Supplier | Nordic Biosite |
Entrez Gene ID | 4804 |
Format | Purified |
Immunogen | Purified CD271 protein isolated from human melanoma cell line A875 |
Isotype | IgG1 |
Keywords | Neurobiology (Veterinary), Neurobiology (Human), CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
Notes | CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells. |
Alias Names | TNFRSF16, NGFR, p75NTR, p75NGFR |
Previous Article No | AFC-4497-2, AFC-7EV6N1-0.1 |
Product Type | Antibodies Primary |
Protocol | Immunohistochemistry (paraffin sections): Recommended dilution: 1-2 μg/ml; Positive tissue: melanoma, heat-mediated antigen retrieval. Flow cytometry: Extracellular and intracellular staining; recommended dilution: 1-4 µg/ml. |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research Area | Neuroscience |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human, rabbit, cat/feline, monkey, mammals |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an intracellular epitope of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within ammino acids 1 - 160. |
UniProt Number | P08138 |
Product Page Updated | 2024-01-03T12:18:20.318Z |