Article No
AFC-PS5E04-0.1
Anti-Hu CD158d Purified
Anti-Hu CD158d Purified
Antibodies Primary
Specifications
| Application | FC, IP, ICC |
| Article No | AFC-PS5E04-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | mAb#33 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD158d Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 3805 |
| Format | Purified |
| Immunogen | NK3.3 cells and KIR2DL4-Ig fusion protein |
| Isotype | IgG1 k |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G. |
| Alias Names | KIR2DL4, KIR103AS, 103AS, 15.212 |
| Previous Article No | AFC-4474-2, AFC-PS5E04-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 2-6 μg/ml. |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals. |
| UniProt Number | Q99706 |
| Product Page Updated | 2024-01-11T15:09:46.355Z |
