The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase protein compound of five identical noncovalently bound nonglycosylated subunits (each subunit 24 kDa; physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes occuring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.) and is also believed to play an important role in innate immunity. Patients with elevated basal levels of CRP are at increased risk for hypertension and cardiovascular disease.
Purified by protein-A affinity chromatography
> 95% (by SDS-PAGE)
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
The antibody C5 recognizes human CRP, an 117 kDa plasma acute phase protein; it recognizes antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
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