SOCS3

Article No AFC-4325-2
Product Type Antibodies Primary
Research Area Cell Signaling
Application WB
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone SO1
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to SOCS3 / Suppressor of cytokine signaling
Supplier BioSite Flow
Immunogen Full-length SOCS3 protein.
Isotype IgG2b
Keywords Cytokine Signaling (Human)
Notes SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot