Article No
AFC-3TF2K0-0.1
Specifications
| Application | IP, WB |
| Article No | AFC-3TF2K0-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | SM2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-STAT1 Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 6772 |
| Format | Purified |
| Immunogen | STAT1 peptide sequence 8-23 (QLDSKFLEQVHQLYD) conjugated to KLH. |
| Isotype | IgG1 |
| Keywords | Cytokine Signaling (Human), Transcription Regulation & Nuclear Proteins (Human), Transcription Regulation & Nuclear Proteins |
| Notes | STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation. |
| Alias Names | CANDF7, IMD31, ISGF3 |
| Previous Article No | AFC-4324-2, AFC-3TF2K0-0.1 |
| Product Type | Antibodies Primary |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Cell Signaling |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The antibody SM2 recognizes an epitope included within amino acids 8-23 of STAT1, a 91 kDa transcriptional factor involved in a variety of systems including antiviral responses and interferon alpha (IFN-alpha) and gamma (IFN-gamma) signal transduction. |
| UniProt Number | P42224 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
