STAT1

Article No AFC-4324-2
Product Type Antibodies Primary
Research Area Cell Signaling
Application IP, WB
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone SM2
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to STAT1
Supplier BioSite Flow
Immunogen STAT1 peptide sequence 8-23 (QLDSKFLEQVHQLYD) conjugated to KLH.
Isotype IgG1
Keywords Cytokine Signaling (Human), Transcription Regulation & Nuclear Proteins (Human), Transcription Regulation & Nuclear Proteins
Notes STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The antibody SM2 recognizes an epitope included within amino acids 8-23 of STAT1, a 91 kDa transcriptional factor involved in a variety of systems including antiviral responses and interferon alpha (IFN-alpha) and gamma (IFN-gamma) signal transduction._x000D_
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human human