Antibodies Primary

SLP76

NEW
Mouse Monoclonal to SLP76

Article No

AFC-4321-2

Application

WB, IHC

Species Reactivity

mouse
human
pig/porcine

Size

0.1 mg

Clone

SLP-76/03

Suggested protocols

Specifications

Application WB, IHC
Article No AFC-4321-2
BioSite Brand BioSite Flow
Clone SLP-76/03
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to SLP76
Supplier BioSite Flow
Immunogen Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Isotype IgG2b
Keywords Adaptor Proteins (Human), Adaptor Proteins (Veterinary), Adaptor Proteins (Rodent), Adaptor Proteins
Notes SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
Product Type Antibodies Primary
Purification Purified by protein-G affinity chromatography
Purity > 95% (by SDS-PAGE)
Research Area Immunology
Size 0.1 mg
Species Reactivity mouse, human, pig/porcine
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The polyclonal antibody reacts with SLP76, a 76kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils; in B cells, however, it is replaced by SLP65.
Product Page Updated 2019-05-20T06:41:23.567Z

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