Antibodies Primary

CD42b

NEW
Mouse Monoclonal to CD42b / GPIb alpha

Article No

AFC-4289-2

Application

FC, IHC, FA

Species Reactivity

human
monkey

Size

0.1 mg

Clone

HIP1

Suggested protocols

Specifications

Application FC, IHC, FA
Article No AFC-4289-2
BioSite Brand BioSite Flow
Clone HIP1
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to CD42b / GPIb alpha
Supplier BioSite Flow
Immunogen Peripheral blood mononuclear cells of a patient suffering with CLL.
Isotype IgG1
Keywords CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Notes CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Product Type Antibodies Primary
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Research Area Immunology
Size 0.1 mg
Species Reactivity human, monkey
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.<br>_x000D_ <b>HLDA IV; WS Code P 40</b>
Product Page Updated 2019-05-16T11:08:57.063Z

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