CD45RB

Article No AFC-4174-1
Product Type Antibodies Primary
Application FC, IP, WB, IHC-P
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone MEM-55
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to CD45RB
Supplier BioSite Flow
Immunogen Human thymocytes and T lymphocytes.
Isotype IgG1
Keywords Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Notes CD45RB is an of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed e.g. in microglia and inflammatory cells.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human, monkey
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The antibody MEM-55 recognizes a siliadase-sensitive epitope of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). CD45RB is expressed on a subset of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells._x000D_ <br><b>HLDA III; WS Code NL 358<br>_x000D_ HLDA IV; WS Code NL 2<br>_x000D_ HLDA V; WS Code T T-151<br>_x000D_ HLDA V; WS Code T T-CD45.08 </b>
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, monkey human monkey