Article No
AFC-PKSBB5-0.1
Application | FC |
Article No | AFC-PKSBB5-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | MEM-129 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD59 Purified Azide Free |
Supplier | Nordic Biosite |
Entrez Gene ID | 966 |
Format | Purified Azide Free |
Immunogen | Human peripheral blood lymphocytes |
Isotype | IgM |
Keywords | CD Antigens & MHC (Veterinary), CD and Related Antigens (Human) |
Notes | CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation. |
Alias Names | MACIF, MAC-IP, protectin, MIRL, HRF-20, HRF20, 1F5, MIN |
Previous Article No | AFC-4096-2, AFC-PKSBB5-0.1 |
Product Type | Antibodies Primary |
Protocol | Functional application: The antibody MEM-129 activates T cells. Flow cytometry: Recommended dilution: 1-4 μg/ml. |
Purification | Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods). |
Purity | > 95% (by SDS-PAGE) |
Research Area | Immunology |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | pig/porcine, human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | HEPES buffered saline (HBS), pH 7.0 |
Technical Specifications | The antibody MEM-129 reacts with CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissus. |
UniProt Number | P13987 |
Product Page Updated | 2024-01-03T12:18:20.318Z |