CD279 / PD-1

Article No AFC-27C56B
Product Type Antibodies Primary
Application FC, IHC-Fr, FA
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone EH12.2H7
Clone Type monoclonal
Conjugation Unconjugated
Description Mouse Monoclonal to CD279 / PD-1
Supplier BioSite Flow
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its receptors CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human, monkey
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The mouse monoclonal antibody EH12.2H7 recognizes CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

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Species reactivity:

human, monkey human monkey