Article No
AC-0100RUO
Application | IHC |
Article No | AC-0100RUO |
Country Availability | SE, FI, DK, NO, IS, FO, GL |
Clone | EP102 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | PDCD4 for Research Use Only |
Supplier | Cell Marque (Epitomics) |
Format | Concentrate |
Notes | Programmed cell death protein 4 (PDCD4) was initially identified as a differentially expressed protein during apoptosis. It acts as a tumor suppressor that inhibits tumor promoter-induced neoplastic transformation. It down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. PDCD4 expression has been found in both normal and tumor cells. Reduced expression of PDCD4 is frequently observed in tumors. Loss of PDCD4 expression has been correlated with tumor progression and prognosis in cancers of the lung, ovary, pancreas and esophagus. Nuclear expression of PDCD4 was associated with a longer disease-free and overall survival rate of esophageal cancer. |
Product Type | Antibodies Primary |
Protocol | IHC: 1:100-200 |
Research Area | Cell Death, Metabolism |
Size | 0.1 mL |
Source / Host | rabbit |
Species Reactivity | human |
Storage | Store at 2-8 °C. Don’t use after expiration date provided on the vial. The users must validate any storage conditions other than those specified. |
Product Page Updated | 2023-10-02T09:48:37.458Z |