Article No
A62843-050
KRT17 Polyclonal Antibody, HRP Conjugated
KRT17 Polyclonal Antibody, HRP Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A62843-050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | HRP |
| Description | KRT17 Polyclonal Antibody, HRP Conjugated |
| Supplier | Epigentek |
| Format | Protein G Purified |
| Immunogen | Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA) |
| Isotype | IgG |
| Keywords | Cellular Structure |
| Notes | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Alias Names | Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17 |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Cell Signaling |
| Size | 50 µl |
| Source / Host | rabbit |
| Species Reactivity | cow/bovine |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | A1L595 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
