Article No
A56106-100
Application | ELISA, WB, IF, IP |
Article No | A56106-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | HSD17B10 Polyclonal Antibody |
Supplier | Epigentek |
Immunogen | Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 protein (2-261AA) |
Isotype | IgG |
Keywords | Cell Metabolism, RNA Processing & Modification |
Notes | Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). _x000D_ |
Alias Names | 17-beta-hydroxysteroid dehydrogenase 10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, HSD17B10, ERAB, HADH2, MRPP2, SCHAD, XH98G2 |
Product Type | Antibodies Primary |
Purity | Protein G purified |
Research Area | Metabolism |
Size | 100 µl |
Source / Host | rabbit |
Species Reactivity | human |
Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
Substrate / Buffer | 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4. |
UniProt Number | Q99714 |
Product Page Updated | 2024-02-13T10:42:34.821Z |