Article No
A51676-100
AATF Polyclonal Antibody, Biotin Conjugated
AATF Polyclonal Antibody, Biotin Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A51676-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | Biotin |
| Description | AATF Polyclonal Antibody, Biotin Conjugated |
| Supplier | Epigentek |
| Immunogen | Recombinant Human Protein AATF protein (6-294AA) |
| Isotype | IgG |
| Keywords | Transcription Factors, Apoptosis & Cell Death, Cell Cycle |
| Notes | May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
| Alias Names | Protein AATF |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Cell Death |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | Q9NY61 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
