Article No
A50072-050
ATXN3 Polyclonal Antibody, Biotin Conjugated
ATXN3 Polyclonal Antibody, Biotin Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A50072-050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | Biotin |
| Description | ATXN3 Polyclonal Antibody, Biotin Conjugated |
| Supplier | Epigentek |
| Immunogen | Recombinant Human Ataxin-3 protein (1-288AA) |
| Isotype | IgG |
| Keywords | Other Histone Modification |
| Notes | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription. |
| Alias Names | Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3 |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Epigenetics |
| Size | 50 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | P54252 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
