Article No
39-2121-100
Specifications
| Application | WB |
| Article No | 39-2121-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | Anti-HDAC3 Polyclonal Antibody |
| Supplier | Abeomics |
| Entrez Gene ID | 8841 |
| Gene Symbol | HDAC3 |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of Human HDAC3(1-18aa MAKTVAYFYDPDVGNFHY), identical to the related Rat and Mouse sequences. |
| Isotype | IgG |
| Notes | HDAC3(HISTONE DEACETYLASE 3) is a member of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC3 gene. The HDAC3 gene is mapped to 5q31.3. HDAC3 has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. The protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. And this gene is regarded as a potential tumor suppressor gene. HDAC3 has an open reading frame of 428 amino acids and shares 53% amino acid identity with HDAC1 and 52% with HDAC2. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. All experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 resulted in loss of enzymatic activity associated with HDAC4. |
| Alias Names | Histone deacetylase 3; HD3; 3.5.1.98; RPD3-2; SMAP45; HDAC3 |
| Product Type | Antibodies Primary |
| Protocol | Western blot : 0.1-0.5µg/ml; Immunohistochemistry(Paraffin-embedded Section) : 0.5-1µg/ml |
| Purification | Affinity Purified |
| Research area | Epigenetics |
| Shipping Information | Blue Ice |
| Size | 100 µg/vial |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| UniProt Number | O15379 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
