Article No
36-2490-20
Application | FC, IF |
Article No | 36-2490-20 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | L243 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Anti-HLA-DRB (MHC II) Monoclonal Antibody(Clone: L243) |
Supplier | Abeomics |
Entrez Gene ID | 3123 |
Gene Symbol | HLA-DRB1 |
Immunogen | Activated human peripheral blood mononuclear cells |
Isotype | IgG2a k |
Notes | This MAb reacts with the HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR, which depends on the correct folding of the heterodimer. This MAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. |
Alias Names | DRB1; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR-beta 1; HLA-DRB1; human leucocyte antigen DRB1; Leucocyte antigen DR beta 1 chain; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell su |
Product Type | Antibodies Primary |
Protocol | Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml) |
Shipping Information | Blue Ice |
Size | 20 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C, -80°C |
Substrate / Buffer | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
UniProt Number | P01911 |
Product Page Updated | 2024-02-06T07:35:53.072Z |