Article No
36-2133-20
Catenin, beta (p120)
Anti-Catenin, beta (p120) Monoclonal Antibody(Clone: 12F7)
Antibodies Primary
Specifications
| Application | FC, IF, WB |
| Article No | 36-2133-20 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 12F7 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Anti-Catenin, beta (p120) Monoclonal Antibody(Clone: 12F7) |
| Supplier | Abeomics |
| Entrez Gene ID | 1499 |
| Gene Symbol | CTNNB1 |
| Immunogen | Recombinant fusion protein consisting of the N-terminal half of human beta-Catenin fused to maltose binding protein |
| Isotype | IgG1 k |
| Notes | Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throµghout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. |
| Alias Names | Cadherin associated protein, beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1 |
| Product Type | Antibodies Primary |
| Protocol | Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Western Blot (1-2ug/ml) |
| Shipping Information | Blue Ice |
| Size | 20 µg |
| Source / Host | mouse |
| Species Reactivity | human, mouse, rat |
| Storage | 4°C, -80°C |
| Substrate / Buffer | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| UniProt Number | P35222 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
