SDF-1α (CXCL12), chemokines, expressed in E.Coli, cross-species reactivity.
Human stromal cell-derived factor-1 (SDF-1α) is a member of the CXCL chemokine family that signals through the CXCR4 receptor. CXCL12 is strongly chemotactic for lymphocytes and induce migration of CD34+ stem cells. In cells expressing the CXCR4 receptor, CXCL12 exerts HIV-suppressive activity.The mature SDF-1α protein is the product of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Human and murine SDF-1 proteins act across species. Recombinant human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues with N-terminus His-tag.
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