Article No
333-C3173-5MG
A-54556A
natural acyldepsipeptide (ADEP) antibiotic
Antibiotics & Culture Media
Specifications
| CAS No | 95398-45-1 |
| MW | 718.9 |
| Article No | 333-C3173-5MG |
| Country Availability | SE, FI, DK, NO, IS, EE, FO, GL |
| Description | natural acyldepsipeptide (ADEP) antibiotic |
| Supplier | APExBIO |
| Notes | IC50: 0.2 µg/ml for Bacillus subtilis 168A-54556A is a natural acyldepsipeptide (ADEP) antibiotic.Acyldepsipeptides (ADEP), a new class of antibiotics, has antibacterial activity against Gram-positive bacteria. The acyldepsipeptides are active against isolates that are resistant to antibiotics, implying a new target identify as ClpP.In vitro: Previous study found that the treatment of B. subtilis with 1.6 mg/ml of A-54556A reduced the number of viable cells by 2 log units. In addition, the biosynthesis of DNA, RNA, protein, cell wall and fatty acid proceeded unhindered for 1 h at 2 mg/ml A-54556A, whereas classical antibiotics were clearly distinguished by preferential inhibition of their target pathway. Microscopic examination showed that after addition of A-54556A at concentrations as low as 0.4 mg/ml, B. subtilis started to form filaments [1].In vivo: Two A-54556A analogs, ADEP 2 and ADEP 4, were proven to be active in the treatment of bacterial infections in rodents. When mice were challenged with a lethal systemic infection of E. faecalis, 1 mg/kg ADEP 2 or 0.5 mg/kg ADEP 4 were sufficient for 100% survival. In lethal sepsis caused by S. aureus, 12.5 mg/kg ADEP 4 rescued 80% of the mice and reduced the bacterial loads in liver, spleen and lung by 2-3 log units compared to an untreated control [1].Clinical trial: Up to now, A-54556A is still in the preclinical development stage.Reference:[1] H. Brtz-Oesterhelt, D. Beyer, H. P. Kroll, et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nature Medicine 11(10), 1082-1087 (2005). |
| Molecular Formula | C38H50N6O8 |
| Product Type | Antibiotics & Culture Media |
| Purity | ≥95% |
| Shipping Information | BLUE ICE |
| Size | 5mg |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| Product Page Updated | 2023-02-16T09:46:40.200Z |
