Article No
333-B6403-50MG
(+)-AJ 76 hydrochloride
Dopamine receptor antagonist
Chemicals & Biochemicals
Specifications
| CAS No | 85379-09-5 |
| MW | 269.81 |
| Article No | 333-B6403-50MG |
| Country Availability | SE, FI, DK, NO, IS, EE, FO, GL |
| Description | Dopamine receptor antagonist |
| Supplier | APExBIO |
| Notes | (+)-AJ 76 hydrochloride is an antagonist of dopamine autoreceptor with pKi values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively. Dopamine receptor is a G protein-coupled receptor and mainly exists in the vertebrate central nervous system (CNS). Dopamine receptor is a receptor for dopamine and plays a critical role in memory, learning, pleasure, cognition, motivation and fine motor control. (+)-AJ 76 hydrochloride is a dopamine receptor antagonist. In rats, AJ76 stimulated locomotor activity and increased the levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and HVA in brain, which were dopamine metabolites [1]. In rats injected with cocaine, (+)-A J76 increased the locomotor stimulation during the first 30 min. However, (+)-AJ76 inhibited the later more intense locomotor stimulation and cocaine-induced stereotypies [2]. In vivo, (+)-AJ76 induced dopamine release mainly through interaction with dopamine receptors in the terminal regions of the A9 and A10 dopaminergic fibers. However, (+)-AJ76 increased the level of DOPAC via the somatodendritic autoreceptors [3].References:[1]. Kullingsjoe H, Carlsson A, Svensson K. Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur J Pharmacol, 1991, 205(3): 241-246.[2]. Piercey MF, Lum JT, Hoffmann WE, et al. Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232. Brain Res, 1992; 588(2): 217-222.[3]. Waters N, Hansson L, Loefberg L, et al. Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo. Eur J Pharmacol, 1994, 251(2-3): 181-190. |
| Molecular Formula | C15H23NO·HCl |
| Product Type | Chemicals & Biochemicals |
| Purity | 98% |
| Shipping Information | BLUE ICE |
| Size | 50mg |
| Solubility | Soluble to 10 mM in H2O |
| Storage | RT |
| Product Page Updated | 2022-04-08T07:36:41.157Z |