Article No
333-B3661-50mg
(+)-Usniacin
Naturally occurring dibenzofuran derivative
Chemicals & Biochemicals
Specifications
| CAS No | 7562-61-0 |
| MW | 344.32 |
| Article No | 333-B3661-50mg |
| Country Availability | SE, FI, DK, NO, IS, EE, FO, GL |
| Description | Naturally occurring dibenzofuran derivative |
| Supplier | APExBIO |
| Notes | MIC: 0.05 µg/62.5 µl to 3.1 µg/62.5 µlMicroorganisms can colonize a wide variety of medical devices, putting patients at risk for systemic and local infectious complications, including local-site infections, endocarditis, and catheter-related bloodstream infections. (+)-Usniacin is a secondary lichen metabolite that possesses antimicrobial activity against various planktonic gram-positive bacteria.In vitro: (+)-Usniacin showed antimicrobial activity against the same microorganisms as that of acetone extract. Among the three analogues it was the most active one having quite low MIC values. Furthermore, (+)-Usniacin did not show any activity against A. hydrophila and B. cereus whereas (D)-usnic acid did. On the other hand, (+)-Usniacin was active against Y. enterocolitica whereas (D)-usnic acid was not active [1]. In vivo: No animal in-vivo study has been reproted so far. Clinical trials: Trials carried out in volunteers showed that mouth-rinse with (+)-Usniacin preparations exerted a selective and long lasting action against S. mutans. The adherence of S. mutans to smooth surfaces was not increased by the presence of subinhibiting concentrations of (+)-Usniacin. These characteristics make (+)-Usniacin a suitable candidate for topical use in oral medicine [2].References:[1] Tay T, Tuerk AO, Yilmaz M, Tuerk H, Kivanc M. Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstictic acid, and protocetraric acid constituents. Z Naturforsch C. 2004 May-Jun;59(5-6):384-8.[2] Ghione M, Parrello D, Grasso L. Usnic acid revisited, its activity on oral flora. Chemioterapia. 1988 Oct;7(5):302-5. |
| Molecular Formula | C18H16O7 |
| Previous Article No | 333-B3661-50MG |
| Product Type | Chemicals & Biochemicals |
| Purity | 99.67% |
| Shipping Information | BLUE ICE |
| Size | 50 mg |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥8.03 mg/mL in DMSO with gentle warming |
| Storage | -20°C |
| Product Page Updated | 2024-03-05T10:50:49.934Z |
