Article No
333-A1032-25mg
CAS No | 88377-68-8 |
MW | 984.18 |
Article No | 333-A1032-25mg |
Country Availability | SE, FI, DK, NO, IS, EE, FO, GL |
Description | Endogenous µ/κ opioid agonist,potent and selective |
Supplier | APExBIO |
Notes | Adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with IC50 value of 10 µM [1].Adrenorphin (metorphamide) is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2) that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain [2].Adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor Met5-enkephalin. When tested with bovine adrenal chromaffin cells, Adrenorphin (metorphamide) showed inhibition on 5 µM nicotine-induced ATP release by almost 50% at 5µM and the inhibition was not in a dose-dependent manner [1]. In bioassays and binding assays, Metorphamide exhibited high µ-binding activity, as well as κ-binding activity with nearly half percent toµ-binding activity, while showed no activity on δ-binding [2].References: [1]. Marley, P.D., K.I. Mitchelhill, and B.G. Livett, Metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. Brain Res, 1986. 363(1): p. 10-7.[2]. Weber, E., et al., Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A, 1983. 80(23): p. 7362-6. |
Molecular Formula | C44H69N15O9S |
Previous Article No | 333-A1032-25MG |
Product Type | Proteins & Peptides |
Purity | 97% |
Shipping Information | BLUE ICE |
Size | 25 mg |
Solubility | insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO |
Storage | -20°C |
Product Page Updated | 2024-03-05T10:50:49.934Z |