Article No
32-6633-50
ACE2 (18-740) Human, Fc
ACE2 (18-740) Human, Fc
Proteins & Peptides
Specifications
| Application | FA |
| Article No | 32-6633-50 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | ACE2 (18-740) Human, Fc |
| Supplier | Abeomics |
| Notes | Source: HEK293 CellsSterile Filtered clear solution.ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries , lungs, heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2,.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors.ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1-9 and Ang II to create the heptapeptide Ang 1-7.The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to Fc tag at C-terminal. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain. |
| Product Type | Proteins & Peptides |
| Protocol | ACE2 activity was measured by its binding ability in a functional ELISA. The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike protein Receptor Binding Domain at 2ug per ml. |
| Size | 50 µg |
| Storage | -20°C |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
