Article No
303-X1717P
Rabbit anti Human Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2)
Rabbit anti Human Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2)
Antibodies Primary
Specifications
| Application | WB, IP |
| Article No | 303-X1717P |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone Type | polyclonal |
| Concentration | Lot specific, see vial |
| Conjugation | Unconjugated |
| Control Tissue | Testis |
| Description | Rabbit anti Human Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) |
| Supplier | Exalpha Biologicals |
| Immunogen | Synthetic peptide derived from human phosphatidic acid phosphatase type 2 domain containing 2 (PPAPDC2) |
| Notes | Upon cell activation Presqualene diphosphate (PSDP)2, a bioactive lipid, rapidly remodels to presqualene monophosphate (PSMP). A newly identified and characterized phosphatase (phosphatidic acid phosphatase domain containing 2 (PPAPDC2)) has recent;y been shown to convert PSDP to PSMP. Also known as Phosphatidic acid phosphatase type 2 domain-containing protein 2. Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP has been shown not to be a substrate for type 2 lipid phosphate phosphohydrolases. PSDP phosphatase activity has been identified in activated human neutrophil (PMN) extracts. Recombinant PPAPDC2 displays diphosphate phosphatase activity with substrate preference for PSDP > FDP phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and optimal at pH 7.0-8.0. PPAPDC2 mRNA has been detected in human PMN, and is widely expressed in human tissues. PPAPDC2 expressed in human PMN is first lipid phosphate phosphohydrolase identified for PSDP. The regulation of this enzymeÕs activity has important implications for PMN activation in innate immunity. |
| Alias Names | Phosphatidic acid phosphatase type 2 domain containing 2, PPAPDC2, PDP, PPAC2 |
| Product Type | Antibodies Primary |
| Protocol | Antibody can be used for Western blotting (1:400-1:800 dilution). Optimal concentration should be evaluated by serial dilutions. |
| Research area | Inflammation |
| Shipping Information | Ship at ambient temperature, freeze upon arrival |
| Size | 10 Miniblots |
| Source / Host | rabbit |
| Species Reactivity | human |
| Stability | See expiration date on vial |
| Storage | Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles |
| Substrate / Buffer | Provided as ligand affinity purified antibody in phosphate buffered saline with 0.1% BSA and 0.08% sodium azide |
| Technical Specifications | Antibody can be used for Western blotting (1:400-1:800 dilution). Optimal concentration should be evaluated by serial dilutions. |
| UniProt Number | Q8IY26 |
| Product Page Updated | 2023-12-29T14:25:47.027Z |
