Antibodies Primary

TIAM

NEW
Mouse anti TIAM

Article No

303-MUB1806P

Application

WB

Species Reactivity

human

Size

0.1 mg

Clone

F5S F6.2

Source / Host

mouse

Suggested protocols

Specifications

Application WB
Article No 303-MUB1806P
Country Availability SE, FI, DK, NO, EE, LV, LT
Clone F5S F6.2
Clone Type monoclonal
Description Mouse anti TIAM
Supplier Exalpha Biologicals
Immunogen F5S F6.2 is a Mouse monoclonal IgG2b antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with T-cell lymphoma invasion and metastasis-inducing protein 1 (Tiam1).
Isotype IgG2b
Notes Tiam1, also known as T-cell lymphoma invasion and metastasis-inducing protein 1, is a protein that in Humans is encoded by the TIAM1 gene. TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain. TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
Product Type Antibodies Primary
Research Area Immunology, Neuroscience
Size 0.1 mg
Source / Host mouse
Species Reactivity human
Storage The antibody is shipped at ambient temperature and may be stored at +4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at +4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Substrate / Buffer Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
Technical Specifications F5S F6.2 is useful for western blot and immunohistochemistry on frozen sections. Optimal antibody dilution should be determined by titration.
Product Page Updated 2020-01-07T12:59:09.171Z

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