Article No
30-2434-100
CD4
Anti-CD4 Monoclonal Antibody (Clone:MEM-241)-PerCP Conjugated
Antibodies Primary
Specifications
| Application | FC, WB |
| Article No | 30-2434-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | MEM-241 |
| Clone Type | monoclonal |
| Conjugation | PerCP |
| Description | Anti-CD4 Monoclonal Antibody (Clone:MEM-241)-PerCP Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 920 |
| Gene Symbol | CD4 |
| Immunogen | 2 N-terminal domains of human CD4 fused to human IgG1 Fc |
| Isotype | IgG1 |
| Notes | CD4 (T4) is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1); IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin Intracellular ligands: p56LckCD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus; CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency). |
| Alias Names | CD4 |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 100 Tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P01730 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
