Article No
30-2305-0.1
Notch 1
PE Conjugated Anti-Notch 1 Monoclonal Antibody (Clone:mN1A)
Antibodies Primary
Specifications
| Application | FC |
| Article No | 30-2305-0.1 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | mN1A |
| Clone Type | monoclonal |
| Conjugation | PE |
| Description | PE Conjugated Anti-Notch 1 Monoclonal Antibody (Clone:mN1A) |
| Supplier | Abeomics |
| Entrez Gene ID | 18128 |
| Gene Symbol | Notch1 |
| Immunogen | GST fusion protein containing cdc10-NCR region of mouse Notch1 |
| Isotype | IgG1 |
| Notes | Notch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands, such as Delta 1, Jagged1 (CD339), and Jagged2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in brain, lung and thymus. |
| Alias Names | Tumor necrosis factor, Cachectin , Tumor necrosis factor ligand superfamily member 2 |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | Q01705 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
