Article No
30-2203-100
CD222 / IGF2 receptor / CIMPR
Anti-CD222 / IGF2 receptor / CIMPR Monoclonal Antibody (Clone:MEM-238)-PE Conjugated
Antibodies Primary
Specifications
| Application | FC, IP, WB |
| Article No | 30-2203-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | MEM-238 |
| Clone Type | monoclonal |
| Conjugation | PE |
| Description | Anti-CD222 / IGF2 receptor / CIMPR Monoclonal Antibody (Clone:MEM-238)-PE Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 3482 |
| Gene Symbol | IGF2R |
| Immunogen | Recombinant Vaccinia virus encoding CD222. |
| Isotype | IgG1 |
| Notes | CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria. |
| Alias Names | IGF2R||MPRI |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 100 Tests |
| Source / Host | mouse |
| Species Reactivity | human, monkey |
| Storage | 4°C |
| UniProt Number | P11717 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
