Antibodies Primary

CD45

NEW
Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-PE Conjugated

Article No

30-2171-100

Application

FC, IP, WB, IHC, ICC

Species Reactivity

human

Size

100 tests

Clone

MEM-28

Source / Host

mouse

Specifications

Application FC, IP, WB, IHC, ICC
Article No 30-2171-100
Clone MEM-28
Clone Type monoclonal
Conjugation PE
Description Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-PE Conjugated
Supplier Abeomics
Immunogen Human thymocytes and T lymphocytes.
Isotype IgG1
Notes CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Alias Names PTPRC||CD45
Product Type Antibodies Primary
Size 100 tests
Source / Host mouse
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
UniProt Number P08575
Product Page Updated 2019-04-24T15:22:26.078Z

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