Article No
30-2161-100
Application | FA, FC, IP |
Article No | 30-2161-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | MEM-25 |
Clone Type | monoclonal |
Conjugation | PE |
Description | Anti-CD11a / LFA-1 alpha chain Monoclonal Antibody (Clone:MEM-25)-PE Conjugated |
Supplier | Abeomics |
Entrez Gene ID | 3683 |
Gene Symbol | ITGAL |
Immunogen | Leukocytes from a pacient suffering from a LGL-type leukaemia. |
Isotype | IgG1 |
Notes | CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. |
Alias Names | ITGAL||CD11A |
Product Type | Antibodies Primary |
Shipping Information | Blue Ice |
Size | 100 Tests |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C |
UniProt Number | P20701 |
Product Page Updated | 2024-02-06T07:35:53.072Z |