Article No
30-2013-100
Application | FC, IHC |
Article No | 30-2013-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | MEM-268 |
Clone Type | monoclonal |
Conjugation | FITC |
Description | Anti-CD30 / Ki-1 Monoclonal Antibody (Clone:MEM-268)-FITC Conjugated |
Supplier | Abeomics |
Entrez Gene ID | 943 |
Gene Symbol | TNFRSF8 |
Immunogen | Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line) |
Isotype | IgG |
Notes | CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. |
Alias Names | TNFRSF8||CD30||D1S166E |
Product Type | Antibodies Primary |
Shipping Information | Blue Ice |
Size | 100 Tests |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C |
UniProt Number | P28908 |
Product Page Updated | 2024-02-06T07:35:53.072Z |