Article No
30-1946-100
CD25 / IL-2R alpha chain
Anti-CD25 / IL-2R alpha chain Monoclonal Antibody (Clone:MEM-181)-FITC Conjugated
Antibodies Primary
Specifications
| Application | FC |
| Article No | 30-1946-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | MEM-181 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | Anti-CD25 / IL-2R alpha chain Monoclonal Antibody (Clone:MEM-181)-FITC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 3559 |
| Gene Symbol | IL2RA |
| Immunogen | PHA-activated peripheral blood leucocytes |
| Isotype | IgG1 |
| Notes | CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas. |
| Alias Names | IL2RA |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 100 Tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P01589 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
