Article No
30-1713-100
Application | FC, IP, WB |
Article No | 30-1713-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | MEM-238 |
Clone Type | monoclonal |
Conjugation | APC |
Description | Anti-CD222 / IGF2 receptor / CIMPR Monoclonal Antibody (Clone:MEM-238)-APC Conjugated |
Supplier | Abeomics |
Entrez Gene ID | 3482 |
Gene Symbol | IGF2R |
Immunogen | Recombinant Vaccinia virus encoding CD222. |
Isotype | IgG1 |
Notes | CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria. |
Alias Names | IGF2R||MPRI |
Product Type | Antibodies Primary |
Shipping Information | Blue Ice |
Size | 100 Tests |
Source / Host | mouse |
Species Reactivity | human, monkey |
Storage | 4°C |
UniProt Number | P11717 |
Product Page Updated | 2024-02-06T07:35:53.072Z |