Article No
30-1701-100
CD31 / PECAM-1
Anti-CD31 / PECAM-1 Monoclonal Antibody (Clone:MEM-05)-APC Conjugated
Antibodies Primary
Specifications
| Application | FC, WB |
| Article No | 30-1701-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | MEM-05 |
| Clone Type | monoclonal |
| Conjugation | APC |
| Description | Anti-CD31 / PECAM-1 Monoclonal Antibody (Clone:MEM-05)-APC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 5175 |
| Gene Symbol | PECAM1 |
| Immunogen | Leukocytes of patient suffering from LGL-type leukaemia |
| Isotype | IgG1 |
| Notes | CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system. |
| Alias Names | PECAM1 |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 100 Tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P16284 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
