Article No
30-1642-0.1
CD16 / FcgammaRIII
Anti-CD16 / FcgammaRIII Monoclonal Antibody (Clone:3G8)-Low Endotoxin
Antibodies Primary
Specifications
| Application | FC |
| Article No | 30-1642-0.1 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 3G8 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Anti-CD16 / FcgammaRIII Monoclonal Antibody (Clone:3G8)-Low Endotoxin |
| Supplier | Abeomics |
| Entrez Gene ID | 2214 |
| Gene Symbol | FCGR3A |
| Immunogen | Human neutrophils |
| Isotype | IgG1 |
| Notes | CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms - FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. |
| Alias Names | FCGR3A||CD16A||FCG3||FCGR3||IGFR3 |
| Product Type | Antibodies Primary |
| Protocol | Flow Cytometry Recommended dilution:6 µg/ml Immunoprecipitation Immunohistochemistry (frozen sections) Application note:acetone fixation Functional Application In vitro Stimulation of NK cell proliferation, blocking of IgG binding and phagocytosis, inhibition of cytotoxic activity, in vivo NK cell depletion |
| Purification | Protein A Purified |
| Shipping Information | Blue Ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P08637 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
