Article No
30-1641-0.1
CD64 / FcgammaRI
Low Endotoxin, Anti-CD64 / FcgammaRI Monoclonal Antibody (Clone:10.1)
Antibodies Primary
Specifications
| Application | FC |
| Article No | 30-1641-0.1 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 10.1 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Low Endotoxin, Anti-CD64 / FcgammaRI Monoclonal Antibody (Clone:10.1) |
| Supplier | Abeomics |
| Entrez Gene ID | 2209 |
| Gene Symbol | FCGR1A |
| Immunogen | Rheumatoid synovial fluid cells and fibronectin purified human monocytes |
| Isotype | IgG1 |
| Notes | CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo. |
| Alias Names | FCGR1A||FCG1||FCGR1||IGFR1 |
| Product Type | Antibodies Primary |
| Protocol | Flow Cytometry Recommended dilution:5 µg/ml Immunoprecipitation Western Blotting Immunohistochemistry Application note:There can occur problems with paraformaldehyde fixation Immunohistochemistry (frozen sections) Application note:There can occur problems with paraformaldehyde fixation Immunocytochemistry Functional Application blocking of IgG binding to the FcgammaR1 |
| Purification | Protein A Purified |
| Shipping Information | Blue Ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P12314 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
