Article No
30-1496-0.1
Drebrin
Anti-Drebrin Monoclonal Antibody (Clone:DBN-N-03)
Antibodies Primary
Specifications
| Application | CyTOF, FC, WB |
| Article No | 30-1496-0.1 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | DBN-N-03 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Anti-Drebrin Monoclonal Antibody (Clone:DBN-N-03) |
| Supplier | Abeomics |
| Entrez Gene ID | 1627 |
| Gene Symbol | DBN1 |
| Immunogen | Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326) |
| Isotype | IgG2b |
| Notes | Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse. |
| Alias Names | Developmentally-regulated brain protein |
| Product Type | Antibodies Primary |
| Protocol | Western Blotting Positive control:REH, Nalm-6, HEK293 cells Mass Cytometry |
| Purification | Protein A Purified |
| Shipping Information | Blue Ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | Q16643 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
