Article No
30-1368-0.1
CD79a
Anti-CD79a Monoclonal Antibody (Clone:HM57)
Antibodies Primary
Specifications
| Application | FC, IHC |
| Article No | 30-1368-0.1 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | HM57 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Anti-CD79a Monoclonal Antibody (Clone:HM57) |
| Supplier | Abeomics |
| Entrez Gene ID | 973 |
| Gene Symbol | CD79A |
| Immunogen | Synthetic peptide corresponding to amino acids 202-216 of human CD79a |
| Isotype | IgG1 |
| Notes | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
| Alias Names | CD79A||IGA||MB1 |
| Product Type | Antibodies Primary |
| Protocol | Flow Cytometry Recommended dilution:5 µg/ml Application note: intracellular staining Immunohistochemistry Recommended dilution:10 µg/ml Immunohistochemistry (frozen sections) Recommended dilution:10 µg/ml |
| Purification | Protein A Purified |
| Shipping Information | Blue Ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | chicken, cow/bovine, guinea pig, horse/equine, human, mammals, mouse, pig/porcine, rabbit, rat |
| Storage | 4°C |
| UniProt Number | P11912 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
