Article No
246-MUB0402S
Rabbit anti Desmin K5
Rabbit anti Desmin K5
Antibodies Primary
Specifications
| Application | IHC, WB |
| Article No | 246-MUB0402S |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | Polyclonal |
| Clone Type | polyclonal |
| Description | Rabbit anti Desmin K5 |
| Supplier | Nordic - MUbio |
| Format | Each vial contains 250 ul Rabbit polyclonal antiSerum containing 0.09% sodium azide. |
| Notes | Desmin is a 53 kDa intermediate filament protein and exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development and muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of desmin and vimentin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed. |
| Previous Article No | 246-MUB0402S |
| Product Type | Antibodies Primary |
| Protocol | K5 is suitable for immunoblotting and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration; recommended range is 1:25 – 1:100 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:100 – 1:500 for immunoblotting applications. |
| Research area | Cell Proliferation |
| Size | 0.25 ml |
| Source / Host | rabbit |
| Species Reactivity | cow/bovine, chicken, goat, hamster, human, mouse, rat, fish |
| Storage | The antibody is shipped at ambient temperature and may be stored at +4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at +4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product. |
| Substrate / Buffer | Each vial contains 250 ul Rabbit polyclonal antiSerum containing 0.09% sodium azide. |
| Technical Specifications | Each vial contains 250 ul Rabbit polyclonal antiSerum containing 0.09% sodium azide. |
| UniProt Number | P17661 |
| Product Page Updated | 2024-01-31T10:35:40.347Z |
