Article No
20-1060-50
Application | IHC, IP, WB |
Article No | 20-1060-50 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | Polyclonal antibody to Daxx |
Supplier | Abeomics |
Entrez Gene ID | 1616 |
Gene Symbol | DAXX |
Immunogen | A synthetic peptide of Daxx protein (amino acids 272-291 ERLINKPGPDTFPDYGDVLR) was used as immunogen for this antibody |
Isotype | IgG |
Notes | Daxx (death-domain-associated protein) was originally identified as a cytoplasmic protein that binds to the death domain of the transmembrane death receptor Fas. It is now that known that the a large porportion of Daxx molecules are nuclear and associate with the promyelocytic leukaemia nuclear body (PML-NB) and other subnuclear domains. Daxx is ubiquitously expressed, and particularly high levels of Daxx have been reported in the thymus and testes. At the cellular level Daxx may be found in cytoplasm and within heterochromatic regions of the nucleus. Daxx has been reported to interact and co-localize with Pml in the nucleus of tumor cell lines and primary cells. Daxx is thought to have both pro- and anti-apoptotic functions depending on the stimulus and the cell type. Although the mechanisms remain to be fully elucidated, research indicates that Daxx plays a role in the pathology of human diseases including cancer and neurodegerative disorders. |
Alias Names | DAXX||BING2||DAP6 |
Predicted Species Reactivity | mouse |
Product Type | Antibodies Primary |
Protocol | WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200 |
Research Area | Cell Death |
Shipping Information | Blue Ice |
Size | 50 µl |
Source / Host | rabbit |
Species Reactivity | dog/canine, human, rat |
Storage | Store the antibody at 4⁰C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Substrate / Buffer | 50 µl sera |
UniProt Number | Q9UER7 |
Product Page Updated | 2024-02-06T07:35:53.072Z |