Article No
182-HM2329-20UG
Application | FS, IA, IF, WB |
Article No | 182-HM2329-20UG |
Country Availability | SE, FI, DK, NO, EE, LV, LT |
Clone | 2D9 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | S100A7, Human, mAb 2D9 – 20 µg |
Supplier | Hycult biotechnology |
Format | 0.2 ml (100 μg/ml) 0.2 µm filtered and protein G purified in PBS+0.1%BSA |
Immunogen | Full length human recombinant protein isolated from E.coli. |
Isotype | IgG1 |
Notes | Antibody 2D9 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7interacts with RAGE which drives an NF-B mediated proinflammatory response and recruitment of neutrophils. S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to and reduces survival of pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior |
Alias Names | Protein S100-A7, Psoriasin, S100 calcium-binding protein A7 Gene name: S100A7, PSOR1, S100A7C |
Previous Article No | 182-HM2329-20UG, HM2329-20UG |
Product Type | Antibodies Primary |
Research area | Immunology |
Shipping Information | Room Temperature |
Size | 20 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. |
Substrate / Buffer | 0.2 ml (100 μg/ml) 0.2 µm filtered and protein G purified in PBS+0.1%BSA |
Product Page Updated | 2024-04-05T09:42:44.568Z |