Article No
182-HM2321-100UG
CD83, Human, mAb ELBE-1 – 100 µg
CD83, Human, mAb ELBE-1 – 100 µg
Antibodies Primary
Specifications
| Application | FC, IA, WB |
| Article No | 182-HM2321-100UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | ELBE-1 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | CD83, Human, mAb ELBE-1 – 100 µg |
| Supplier | Hycult biotechnology |
| Format | 1 ml (100 μg/ml) 0.2 μm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide. |
| Immunogen | huCD83Ig fusion protein |
| Isotype | IgG1 |
| Notes | Monoclonal antibody ELBE-1 recognizes human CD83. CD83 is a cell surface marker predominantly expressed on mature DCs. Expression has been found on circulating and tissue DCs. Additionally CD83 is found on activated B and T lymphocytes. Human CD83 is composed of 205 amino acids but has, due to extensive glycosylation, a molecular weight of ca 45 kDa. CD83 is expressed as a conserved a noncovalently associated single chain molecule membrane protein. CD83 is considered a marker for fully matured dendritic cells in the peripheral circulation. An essential role has not been found. However, its function primarily lies in the regulation of T- and B-cell maturation and the regulation of their peripheral responses. CD83 is supposed to function as a co-stimulator for T-cell activation similar to CD80 or CD86. Enhanced expression on DCs correlates with their T cell activating capacity. Besides the membrane version of the protein also a soluble form occurs (sCD83). sCD83 levels are raised in sera from patients of chronic lymphocytic leukemia and other haematological malignant diseases and in the synovial fluid of rheumatoid arthritis. While the membrane bound form has immune stimulatory capacity, the soluble form has the opposite effect and is considered to have immunosuppressive potential. Due to its inhibitory functions, sCD83 has potential for treatment of eg. autoimmune diseases and transplantation. In contradiction to most clones, antibody ELBE-1 is besides flow cytometry applicable in western blotting and ELISA (detecting of sCD83). ELBE-1 recognizes a linear epitope and doesn’t influence T cell activation. |
| Alias Names | B-cell activation protein, Cell surface protein HB15 |
| Previous Article No | 182-HM2321, 182-HM2321-100UG, HM2321-100UG |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | Room Temperature |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. |
| Substrate / Buffer | 0.2 ml (100 μg/ml) 0.2 μm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide. |
| Product Page Updated | 2024-04-05T09:42:44.568Z |
