Article No
182-HM2109-20UG
Application | FC, FS, IA, IP, WB |
Article No | 182-HM2109-20UG |
Country Availability | SE, FI, DK, NO, EE, LV, LT |
Clone | M241 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Activated C1s |
Supplier | Hycult biotechnology |
Format | 0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS containing 0.1% bovine serum albumin. |
Isotype | IgG2a |
Notes | Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s. |
Previous Article No | 182-HM2109-20UG, HM2109-20UG |
Product Type | Antibodies Primary |
Research Area | Immunology |
Shipping Information | Room Temperature |
Size | 20µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year. |
Substrate / Buffer | 0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS containing 0.1% bovine serum albumin. |
Product Page Updated | 2023-12-29T14:10:53.573Z |